The Effect of Atorvastatin on Serum Inflammatory Factors in Patients with Diabetic Macro-angiopathy 

Wenjing Zhao1, Junmei Wu2, Xiaomin Liu2, Yanlu2, Zhixin Zuo2 

1Neurology Department Affiliated Hospital of Hebei University of Engineering, Handan, 056002, China 

2The People’s Hospital of Handan City, Handan, 056001, China 

Abstract: Objective to observe the effect of atorvastatin on serum high-sensitivity-reactive protein (Hs-CRP) and interleukin-8 (IL-8) in patients with diabetic macro-angiopathy .Methods 110 patients with type 2 di-abetes incorporated large vascular complications were randomly divided into experimental group and control group. The control group given general treatment, the experimental group on the basis of this combined with atorvastatin 40 mg/d, were observed 12 weeks. All the subjects were determined the serum Hs-CRP, IL-8 and fasting blood glucose and blood lipids before treatment and after it for 4 weeks, 8 weeks and 12 weeks.There was no statistically significant difference in serum Hs-CRP and IL-8 level between the two groups before treatment (P>0.05).There was no statistically significant difference in serum Hs-CRP and IL-8 level between the two groups before treatment (P>0.05). it was significantly reduced with the prolonged treatment time that the levels of plasma Hs-CRP and IL-8 in the treatment group (P<0.05),experimental group was significantly lower than the control group After treatment (P<0.05). It was positively correlated between Plasma Hs-CRP and IL-8 (P<0.01).Inflammatory factors Hs-CRP and IL-8 were involved in the development of diabetic ma-cro-angiopathy complications. It is possible for atorvastatin to suppression that progression of diabetic macro-angiopathy lesion by inhibiting inflammatory response. 

Keywords: Diabetes; Atorvastatin; Inflammation; Hs-CRP; IL - 8