Initial Symptom of Upper Respiratory Infection in Chronic Eosinophilic Leukemia with FIP1L1/PDGFRA Rearrangement: Recovery with Iimatinib 

Keyu Liu1, Yanfang Yu2, Huijuan Song3, Xueqin Wang1, Zexian Fu4* 

1Departments of Clinical Laboratory, Affiliated Hospital of Engineering University of Hebei, Hebei, 056002, China 

2Departments of Hematology, Affiliated Hospital of Engineering University of Hebei, Hebei, 056002, China 

3Departments of Laboratory, Affiliated Zhongshan Hospital of DAlian University, Liaoning, 116001, China 

4Departments of Science and Education, Affiliated Hospital of Engineering University of Hebei, Hebei, 056002, China *Corresponding author 

Abstract: This article intended to present and analyze a patient with factor interacting with PAPOLA and CPSF1/platelet-derived growth factor receptor α(FIP1L1/PDGFRA)-associated chronic eosinophilic leukemia (CEL) to probe the characteristics in the diagnosis, treatment, and prognosis of the disease. Methods: We re-trospectively analyzed the clinical data of a patient with FIP1L1/PDGFRA-positive CEL. Results: Clinical features of the case is upper respiratory infection as initial symptom. The patient presented with increased white blood and eosinophil count in peripheral blood, mild anemia, multiple lymph node enlargement, sple-nomegaly, and cytogenetic variation of positive FIP1L1/PDGFRA. Conclusion: The clinical features of CEL is clonal proliferation of eosinophil, The peripheral blood and bone marrow are always involved. Tissue infil-tration by eosinophils and the release of cytokines and humoral factors from the eosinophil granules result in damage of tissue in numbers of organs. Gene targeting treatment using imatinib led to quick and effective re-covery for the Patient. 

Keywords: Chronic eosinophilic leukemia; FIP1L1/PDGFRA; Imatinib; Upper respiratory infection