Clinical Significance of D-dimer,SF and LDH Levels in Patients with Acute Leukemic 

Keyu Liu1, Huijuan Song2, Meirong Li3, Yantao Su4, Yanhong Wang3, Ling Qiao3, Congmin Wang1, Yuhang Sun1, Shujing Qi1, Zexian Fu1*

1Affiliated Hospital of Engineering University of Hebei, Handan, 056002, China 

2Departments of Laboratory, Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, China 

3Departments of Internal Medicine, People's Hospital of Handan, Handan, 056001, China 

4Room of Blood Collection, Infectious Disease Hospital of Handan, Handan,056001, China 

*Corresponding author 

Abstract: Objective: This study aimed to investigate the clinical significance of plasma D-dimer,serum ferri-tin (SF) and lactate dehydrogenase(LDH) levels to determine the useful laboratory markers for diagnosing acute leukemia. Methods: We compared laboratory data such as D-dimer,SF and LDH levels in AML non-APL, APL and ALL group with that in normal control group, and we also compared D-dimer,SF and LDH le-vels among AL patients before the first cycle of chemotherapy (newly diagnosed group), complete remission after chemotherapy (CR group), and relapse after complete remission in 1 year (recurrent group).Results: 1.The D-dimer,SF and LDH levels in AML non APL group, APL group and ALL group are significantly higher than that in normal control group( P<0.05). LDH and SF levels in AML non-APL group, APLgroup and ALL group were compared, the difference was no statistical significance(P>0.05). D-dimer level in APL group was significantly higher than that in AML non-APL group and ALL group( P<0.05).2. D-dimer, LDH and SF levels in CR group were significantly lower than that in newly diagnosed group and recurrent group ( P <0.05). There was no statistical differences between recurrent group and newly diagnosed group, and there was no statistical differences between normal control group and CR group in D-dimer, LDH and SF levels ( P>0.05).Conclusion: Detection of plasma D-dimer is particularly valuable in clinical diagnosis of APL. D-dimer, LDH and SF can be used as indicators in diagnosis and curative effect evaluation and prognosis judge for patients with AL. 

Keywords: Acute leukemia; D-dimer; Serum ferritin; Lactate dehydrogenase