Different pH-values of Release Medium Influence the Drug release from PTX-PCL Microspheres

Jinzhu Wang

Hebei University Baoding, China

Abstract: In this paper we study in vitro dissolubility of paclitaxel-loade polycaprolactone sustained-release microspheres. Different pH values release medium of is used to simulate pH conditions in different parts of body, and determination the paclitaxel in Microspheres by High Performance Liquid Chromatography according Chinese Pharmacopoeia 2010. The experimental results indicate that the microspheres release rates of same drug loading content in buffer solution of pH 7.35 is the fastest, and in the pH 1.2 is the slowest. The drug release behavior according to the first-order model and it is not affected by drug loading rate of microspheres. The prepared paclitaxel-loade polycaprolactone sustained-release microspheres has good sustained release effect in different release media, and the results can provide references for further study of in vivo release.

Keywords: Different pH-values, paclitaxel, polycaprolactone, microspheres