The Relationship between Plasma Type B Brain Natriuretic Peptide Precursor, CTNI, Platelet Activation Factor and Prognosis in Elderly Patients with Advanced Cerebral Infarction

Wenjing Zhao1*, Junmei Wu2, Xiaomin Liu2, Lu Kong2, Liping Wang2

1Department of Neurology, Affiliated Hospital of Hebei University of Engineering, Handan, 056008, China

2Department of medicine people's hospital of Handan city, Handan, 056008, China

Abstract: To study the effect of plasma levels of Plasma type B brain natriuretic peptide precursor, Cardiac troponin I, Platelet alpha - granular membrane protein and Platelet aggregation rate on the prognosis of elderly patients with advanced cerebral infarction. Methods: There were included 86 cases of elderly patients with advanced cerebral infarction admitted to our hospital from March 2016 to March 2019 .The concentrations of NT-proBNP, CTN-I, GMP-140 and PAgT were detected in all patients within 24 hours of onset. The patients were divided into three groups, and It were observed the levels of NT-proBNP, CTN-I, GMP-140 and PAgT in patients with different cerebral infarction according to NHISS and BI scores on admission. Patients were followed up for 6 months, 6 of whom died within 3 months. The patients were followed up for 6 months, 6 of whom died within 3 months. The difference value of NIHSS scores is greater than four is considered good prognosis, while NIHSS score is less than considered poor prognosis according to the difference value of two NIHSS scores. To compare the levels of related indicators, which NT-proBNP, CTN-I, GMP-140 and PAgT, in the survival and death cases, the good prognosis group and the poor prognosis group. Conclusion: It was significantly increased that the level of NT-proBNP, CTN-I, GMP-140 and PAgT in patients with progressive cerebral infarction, and the prognosis was worse. It can be used as clinical indicators to observe the prognosis of senile patients with advanced cerebral infarction.

Keywords: Cerebral infarction; NT-proBNP; CTN-I; GMP -140; PAgT