Rui Hou, MingtaiWang, QingqingXie, QiangweiBai

Nursing School of Sias University, Xinzheng,451150, China

Abstract: Objective: To discuss the effect of plasma neutrophilelastase (NE), endothelin -1 (ET-1) levels and lung function on continuousblood purification(CBP) treatment foracute respiratory distress syndrome (ARDS). Methods: 73 ARDS patientswere selected and randomly divided into observational group (n = 39)and control group (n = 34), patients on control group receivedconventional treatment, and observational group added CBP treatment. The plasmaNE, ET-1 levels were detected before treatment (T0), 1d post-treatment (T1), 2d(T2), 3d (T3) respectively, and the alveolar oxygenation function, airway functionwere compared between the two group. Results: Compared with the control group,the plasma NE levels at T2, T3 and plasma ET-1 levelsat T1, T2, T3of observational group and were significantly reduce(P <0.05). Comparedwith T0, the PaO2 at T3 of both groupswere significantly rise, and PaCO2, PaO2 / FiO2 were significantly reduce(P <0.05), and PaO2,PaCO2, PaO2 / FiO2 of observational group weresignificantly lower than that of control group(P <0.05);Compared with T0, theFEV1, FEV1 / FVC of both groups were significantly reduce(P <0.05), andobservational group were significantly lhigher than that of control group(P <0.05).Conclusion: CBP can improvealveolar oxygenation function, airway function, and its mechanism involving the elimination of plasma fraction NE ARDS patients, ET-1, anti-inflammatory.This electronic document is a “live” template. The various components of yourpaper [title, text, heads, etc.] are already defined on the style sheet, asillustrated by the portions given in this document.

Keywords: Acute respiratory distress syndrome; Continuous blood purification;Neutrophil elastase; Endothelin-1