Xuehai Lv¹, XianpingLi², Gaiping Shi³, Junfang He¹, Fei Wu¹, ZhigangWang¹, Wenjing Zhao⁴*

¹Department ofNeurology, The Central Hospital of Handan City, Handan,056008,China

²Department of Liver,The InfectiousDisease Hospitalof Handan City, Handan,056002,China

³Gynecologydepartment, Quzhou County Hospital of Handan City, Handan, 057250,China

⁴Department ofneurology, Affiliated Hospital of Hebei University of Engineering, Handan,056002,China

Abstract: Purpose To investigate the effects of levels of vascularendothelial growth factor (VEGF), superoxide dismutase (SOD) andmalondialdehyde (MDA) in the serum of acute cerebral infarction by fibrinolyticenzyme combined with ginkgo biloba extract with oxygen inhalation. Methods It wereselected that 106 patients with acute cerebral infarction who visited thehospital from January 2014 to December 2015, All the patients were divided intostudy group and control group according to the treatment method and 53 cases ineach group. Both groups were treated with conventional therapy and fibrinolyticenzyme therapy. The study group was given ginkgo biloba extract inhaled withoxygen while the control group was given pure oxygen inhalation. It wasdetected that the levels of VEGF, SOD and MDA in Serum before and aftertreatment. Results It was no significant difference that the levels of VEGF,SOD and MDA in serum before treatment in two groups (P > 0. 05). It washigher that levels of VEGF and SOD in Serum after treatment than before in thetwo groups, and MDA levels were lower than before (P < 0. 05). Aftertreatment, it  was higher that VEGF andSOD levels in the study group than those in the control group, and  MDA levels were lower than in the controlgroup (P < 0. 05). Conclusion It can effectively increase the levels of VEGFand SOD, and reduce the level of serum MDA via fibrinolytic enzyme combinedwith ginkgo biloba extract ad-jointed oxygen inhalation in the treatment ofacute cerebral infarction

Keywords: Cerebralinfarction; Fibrinolytic enzyme; Ginkgobiloba extract; Vascular endothelial growth factor subclass; Superoxidedismutase; Malondialdehyde