Clinical Significance of MCV，MPV,  SF and LDH Levels in Old Patients with Myelodysplastic Syndromes 

Keyu Liu1, Mengmeng Geng2, Na Jin3, Juan Zhan3, Hongxia Wang4, Zexian Fu5*

1Department of Clinical Laboratory, Affiliated Hospital of Engineering University of Hebei, Hebei, 056002, China

2Department of Intensive Care Unit, Affiliated Hospital of Engineering University of Hebei, Hebei, 056002, China

3Department of Clinical Laboratory, People's Hospital of Handan, Hebei, 056001, China

4Department of Internal Medicine, People's Hospital of Handan, Hebei, 056001, China

5Department of Science and Education, Affiliated Hospital of Engineering University of Hebei, Hebei, 056002, China

*Corresponding author

Abstract: Objective: The aim of this study was to investigate the clinical significance of  mean corpuscular volume (MCV), mean platelet volume (MPV), serum ferritin (SF) and lactate dehydrogenase(LDH) levels to determine the useful laboratory markers for diagnosis and prognostic evaluation of MDS.Methods: MCV，MPV,  SF and LDH levels were compared in MDS group with that in normal control group. MDS patients were divided into 4 groups according to the International Prognostic Scoring System ( IPSS): low -risk， in-termediate risk-Ⅰ， intermediate risk-Ⅱ and high-risk． We compared MCV，MPV,  SF and LDH levels among the four groups. Results: 1.The MCV，MPV,  SF and LDH levels in MDS group are significantly higher than that in normal control group(all P<0.05). 2.There were significant differences in serum LDH le-vels among the 4 groups of MDS (all P ＜0.05)，and serum LDH levels increased in turn: low -risk， inter-mediate risk Ⅰ， intermediate riskⅡand high-risk. There were no significant differences in MCV, MPV, and SF levels among four groups.(all P>0.05)Conclusion: Detection of the MCV，MPV,  SF and LDH levels is valuable in clinical diagnosis of MDS, and the LDH level seems to be valuable for prognostic evaluation of the MDS besides IPSS scoring system．

Keywords: Myelodysplastic syndromes; MCV; MPV; Serum ferritin, Lactate dehydrogenase