Effect of Indexes of Liver Function and Indicators of Hepatic Fibrosis  in Patients with Primary Liver Cancer after Interventional for Treatment of Postoperative with Magnesium Isoglycyrrhizinate

Wenjing Zhao1*, Ronghua Hou2, Ting Liu3, Liping Hu2 , Min Li2 , Wenjuan Xin2

1Affiliated Hospital of Hebei University of Engineering,  Handan, 056002, China

2People’s Hospital of Handan, Handan, 056001, China

3Hebei Province Special Care Hospital, Shijiazhuang, 050057, China

*Corresponding author

Abstract: Objective Observe the effect of indexes of liver function and hyaluronic acid (HA), type IV colla-gen (IV-C)and laminin (LN)  in patients with primary liver cancer after interventional for treatment of post-operative with magnesium isoglycyrrhizinate. Methods They were randomly divided into treatment group (40 cases) and control group (40 cases) that 80 patients with primary liver cancer after international therapy. The control group was given routine therapy (mainly tiopronin), the treatment group was received magnesium isoglycyrrhizinate. Compared alanine aminotransferase (ALT), prothrombin time (PT), total bilirubin ((TBIL), hepatic pro-thromboplastin test (HPT) ,Hyaluronic acid (HA), type IV collagen (IV-C)and laminin (LN)of livers between two groups, the dosage of diuretic and relevance safety. Results There were statistically significant that in the ALT, TBIL, PT, HPT HA,IV-C and LN  between treatment group and control group after ten days. It was not found that drug allergies, heart palpitations, dizziness, skin rashes and other adverse reactions with magnesium isoglycyrrhizinate. The efficacy of magnesium isoglycyrrhizinate about liver injury and  liver fibrosis after interventional treatment is relatively safe for widespread clinical application.

Keywords: Magnesium isoglycyrrhizinate; Primary liver cancer; Intervention therapy; Lliver fibrosis; Liver function